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Archive for August, 2009

Announcing A New Infertility Resource: FertilityWire

Wednesday, August 26th, 2009
The PFC Staff, as a unified team, is guided by the highest ethical standards. We provide our patients with the best quality, individualized, compassionate fertility care.
More about The PFC Staff · Read Other Posts

We are excited to introduce a new website FertilityWire, http://fertilitywire.com.  This site is separate from our current website www.pacificfertilitycenter.com.

FertilityWire will provide access to a wealth of fertility information, news, and social content. Please take a moment to check out this exciting new resource. You can let us know what you think in the comments section.

Enjoy!

-Robb Mayberry, Director of Development

Our Story, “All My Favorites”

Wednesday, August 19th, 2009
The PFC Staff, as a unified team, is guided by the highest ethical standards. We provide our patients with the best quality, individualized, compassionate fertility care.
More about The PFC Staff · Read Other Posts

Steve and I met and fell in love in our twenties. We both thought we would want children “some day.” Eleven years later we realized “some day” had finally arrived. I was thirty-six then, but I never thought we would have any problems conceiving. My mom had three children in her late thirties and into her forties.

After six months with no success, my doctor ran the usual tests and found nothing wrong, so my OB recommended going to PFC. We did one IUI, then decided to move on to IVF. My first IVF cycle failed. We were preparing for the second when we were delighted to findout I was pregnant naturally. I gave birth to a healthy baby boy.

We wanted more children, and as it had taken two and a half years to conceive Alan, we decided to start trying again straight away. We weren’t so lucky this time, so after 18 months we were back at PFC talking to Dr. Givens about doing IVF again. Then we discovered a new problem – my FSH was now elevated. So, now I also had decreased ovarian reserve in addition to unexplained infertility.

We tried four cycles of IVF with my own eggs. I did get pregnant on my third cycle, but sadly miscarried at eleven weeks. I was now forty-two and felt it was time to move on.

Now we faced decision time-do we give up, move on to donor egg, or move to adoption? We were both sure we wanted more children, and I felt that by carrying the child I would feel that it was truly mine, even if I didn’t have the biological connection. Oddly enough, it was harder for Steve to move on to an egg donor. But after lots of talking it through, he felt it was the best choice for our family too.

We met with Peggy the PFC counselor, who was very helpful. Dr. Givens thought an egg donor was a great option for us. She said that with a transfer of two blastocysts, our chances of conceiving were about 80%. We ended up with a short list of two potential donors. One was a perfect match on paper—my height, my hair color, my eye color, with the right ethnic background. The second wasn’t such a perfect match, but I just felt a really strong connection to her. I really felt that if we met in real life we would be friends. In my mind I kept going back to something Peggy had said “pick someone you really like”, it was great advice. We went with donor number two, and are very happy with our choice.

Initially everything went well, but then on day three we received a phone call asking us to come in. Our embryos were looking very stressed. Most were grade three with low cell count. We transferred the best three and prayed.

On the day of our beta pregnancy test, Ann (one of the nurses at PFC) called to give us the good news. I was pregnant! Once we saw the heartbeats, we told our son Alan, “Mommy has two babies growing in her tummy,” and he was thrilled. Feeling those babies kicking and squirming around inside, I had no doubt whose babies they were—I might not have provided the eggs, but my body turned those little seven or eight celled embryos into two beautiful children.

The first day Alan got to meet his new brother and sister the look on his face said it all. It was love at first sight. He has made a wonderful big brother, the twins adore him, and our family now feels complete. I feel truly lucky when I look at my three wonderful children. I am very grateful to Dr. Givens and all the wonderful staff at PFC, and especially to our donor.

Some people may wonder, if I love all of my children the same. They have three very different personalities, so I love them all differently; but I do love each one as much as the other. In the words of one of our favorite books, they are “all my favorites.”

—Submitted by Trisha (PFC patient)

What Everyone Should Know About Ethnic-Based Genetic Screening Before Pregnancy

Wednesday, August 12th, 2009
The PFC Staff, as a unified team, is guided by the highest ethical standards. We provide our patients with the best quality, individualized, compassionate fertility care.
More about The PFC Staff · Read Other Posts


Many populations of the world have specific genetic conditions that are prevalent within their ethnic group. Consequently, numerous medical organizations have recommended that genetic screening for these conditions should be offered when women are either planning for, or are currently pregnant. We are all carriers of genetic conditions: generally this is of little concern, as it is highly unlikely that we would have children with a partner who is a carrier for the same condition.

The genetic conditions listed in the table below are recessive. A recessive gene mutation is “carried” by someone who is unaffected by the disease, and thus unaware of their carrier status. Men and women have equal potential to be carriers for recessive conditions. Even if someone is a carrier, we would not expect to see a family history of the disease. If there is a family history, the likelihood of being a carrier of that condition is generally greater than in the general population. Being a carrier for a genetic condition typically has no impact on the carrier’s health and development. However, if a carrier has a child with another carrier of the same genetic disease, the chance that the child will be affected with the disease is 1 in 4 (25%).

If only one partner is a carrier, and the other tests negative, then the risk of an affected child is low, but not zero (a result of the limited ability to test for all defects that would make one a carrier; see table). These genetic screening tests are typically performed on a blood sample.

Below is a table listing the minimum number of tests for various ethnic groups recommended by the physicians at Pacific Fertility Center prior to starting assisted reproduction treatment. Additional genetic tests may be considered after a discussion with your physician.

If you know that both you and your partner are carriers of the same genetic defect, you may be able to have embryos created in an IVF cycle and tested for their status. Preimplantation genetic diagnosis (PGD) is a technology that allows embryos to be tested for specific disease causing mutations. PGD can identify unaffected embryos for transfer back to the uterus or freezing.

—Guest Contributor – Certified Genetic Counselor Lauri Black, M.S., C.G.C

Ancestral Population Genetic Desease Carrier Frequency Detection Rate*
All cystic fibrosis Approximately 4% in people of European (and Ashkenazi Jewish) ancestry and less common in other populations Approximately 88% for Europeans, 94% for Ashkenazi Jewish ancestry, less accurate for others
Ashkenazi (Eastern European) Jewish ancestry cystic fibrosis, Tay Sachs, Canavan, familial dysautonomia Approximately 3% for Tay Sachs, 2% for Canavan and 3% for familial dysautonomia Approximately 94-99%, (depending on the condition tested)
African/African-American, Chinese, Southeast Asian, or Mediterranean ancestry Hemoglobinopathies, such as sickle cell anemia and thalassemia Approximately 10% of African-Americans are sickle cell carriers; 5-6% of Asians and 12% of some Mediterranean populations are thalassemia carriers. Variable depending on method, but very high (in the 90 percentiles)

*See lab specific accuracies on test result

 
Welcome to InfertilityDoctor.com, blog of Pacific Fertility Center. Located in San Francisco, California, PFC is the leading Bay Area infertility clinic specializing in PGD: preimplantation genetic diagnosis, IVF: in vitro fertilization, egg donor programs, embryo freezing, ICSI & IVF as well as other advanced female and male infertility treatment solutions. Our office is conveniently located near the Bay Bridge and is accessible to those traveling from Bay Area communities such as the East Bay (Berkeley, Oakland, and Walnut Creek), North Bay (Marin and Santa Rosa), Peninsula (San Mateo), and South Bay (San Jose). Our office is also less than an hour-and-a-half from Northern California communities such as Sacramento and Stockton.
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