Every year thousands of families are created with the assistance of in-vitro fertilization. Many of those newborns are twins. While some may see this as a double blessing, it is important to understand that there are many potential risks associated with multiple gestation. Statistics show that a higher percentage of twins are born prematurely compared to singleton pregnancies. Premature birth can cause complications resulting in physical impairment, learning disabilities, and even death. In addition to the increased risk to the children born from a multiple pregnancy, there is also an increased risk for the pregnant woman of complications associated with carrying multiples.

Pacific Fertility Center (PFC) has been taking steps to minimize the risk of multiple gestation for several years. “We have worked actively to increase pregnancy rates and decrease the number of multiples,” comments Carolyn Givens, M.D. “Balancing high pregnancy rates with low pregnancy risk improves pregnancy outcomes. Our goal is to achieve this balance and reduce the risk of multiple gestation.”

PFC recently completed the analysis of our Elective Single Embryo Transfer (eSET) program for 2009. The twin rate was significantly lower, and, triplets were eliminated entirely. 79 patients underwent an embryo transfer procedure where they elected to transfer only one embryo created from their own eggs; these 79 transfers resulted in 38 pregnancies, two of which were identical twin pregnancies (the embryo split from one into two) and NO triplets. Compare this statistic to patients choosing to transfer two embryos: 159 patients, with embryos derived from their own eggs, transferred two embryos resulting in 80 pregnancies, of which 31% were non-identical twins and two triplet pregnancies (again from one of the embryos splitting).

Patients that choose eSET have excellent pregnancy rates with a single embryo. eSET embryos are grown for 5 days in the lab to the blastocyst stage, which allows for selection of the healthiest embryos for transfer. The transfer of fewer embryos provides for the healthiest outcomes; eSET produces high pregnancy rates while minimizing the risk of multiple pregnancy. “For many patients, there is no advantage to transferring more than one embryo. It is all about educating our patients. Given this information, these numbers and the potential risks of twin pregnancies, many will choose to transfer only one embryo,” says Carolyn Givens, M.D.

At PFC, careful consideration is given to the number of embryos transferred to each patient. Our goal is to create healthy singleton pregnancies. Utilizing advanced embryo culture techniques, the highest quality embryos can be selected for transfer. Special environmental conditions, advanced culture media, and the delicate handling of gametes and embryos is required; these efforts result in better embryos, with higher implantation and pregnancy rates.

In addition, PFC has developed an outstanding and robust program for freezing embryos not transferred in the fresh cycle. Using a technology called vitrification, we have been able to achieve pregnancy rates with frozen embryos that are very similar to those using fresh embryos. “The outstanding success of our freezing program has allowed us to be confident in transferring just one embryo at a time, which all but eliminates the risk of triplets or higher pregnancy,” says Dr. Joe Conaghan, PFC Lab Director. He adds, “We have been so successful with embryo freezing over the last 3 years that our embryologists are in high demand to provide training across the country and around the world. Our goal is to help our patients overcome infertility and build their family; one healthy baby at a time.”

Tune your radios to KGO 810 AM, tonight. Dr. Givens will be the featured guest on the Pat Thurston Show from 10 – 11 p.m. PST. Dr. Givens will be discussing many fertility issues including treatments, outcomes, and ethical issues. She will also be taking questions from callers. You may also stream the show live on the KGO website.

UPDATE: This study is currently on hold while we attend to some administrative details. Please check back to this blog often, as we will keep our readers updated.  You may also call the New Patient Coordinators at 415 834-3095 for more information.

PREVIOUSLY: Pacific Fertility Center is pleased to announce that as of October 1st we are enrolling patients into a groundbreaking research study to determine the value of combining acupuncture with IVF. Traditional

Chinese medicine has been practiced in throughout Asia for thousands of years:in the last decade, the west has been following suit.

There have been sufficient peer reviewed studies to warrant a clinical trial in which there are predictable parameters of patient involvement. One of the first studies involving acupuncture and IVF was published by Paulus et al in the journal Fertility Sterility in 2002. The Paulus study reported the influence of acupuncture on the pregnancy rate in patients who undergo assisted reproductive therapy. Clinical pregnancies were documented at 42.5% of patients in the acupuncture/IVF group, whereas pregnancy rates were 26.3% in the control group, using IVF alone. In this study, the acupuncture was performed before and after embryo transfer only.

How does acupuncture affect fertility? A review article in Alternative Therapies (Anderson 2007) suggested four possible mechanisms by which acupuncture could improve the outcome of IVF: modulatingneuroendocrine factors; increasing blood flow to the uterus and ovaries; modulating cytokines; and reducing stress, anxiety, and depression.

Pacific Fertility Center and The Fertility Flash would like to invite you to a special Valentine’s Day event.
Do You Love Your Genes? Tweetup/Meetup (a Valentine’s Day event)
Thursday February 11, 2010 at 5:30pm
Pacific Fertility Center’s Education Center
55 Francisco St., Suite 550
San Francisco, California 94133 Get Directions

Please join us for genes, love, award-winning wine, chocolate, and tasty, healthy appetizers!

To view the invitation, click here

This is an in-person and virtual event for all who would like to participate and learn about the leading edge of genetics and fertility. We will also be tweeting live during the event to communicate with and connect tweeters.

Genes are an important part of life, especially for those who are struggling to conceive a child.  At this event we will celebrate these building blocks of life in all forms, whether they come from biological parents, birth parents, or donors.

We will also be joined by representatives from Counsyl and the Gene Security Network (GSN) to speak about their cutting edge genetic testing technologies.

For more details on our presenters see:

Pacific Fertility Center: http://pacificfertilitycenter.com
Counsyl: http://counsyl.com
GSN: http://genesecurity.net

**

Please RSVP at rsvp@fertilitywire.com or on Facebook at http://bit.ly/bopZUZ

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insights founded by fertility doctors. Visit us: http://fertilitywire.com

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—Best regards from all of us at Pacific Fertility Center.

Imagine a website that allows you to search for the very latest information on fertility. Well, it’s here and it’s called fertilitywire.com.

PFC is proud to present fertilitywire.com as a completely unique website that offers real-time and fresh information on fertility and infertility related topics. It’s a resource for people engaged in the process of becoming pregnant through fertility treatments or people studying this field who want to explore it.

And, it’s a unique resource in that it’s powered by a type of search called “browsing or universal search,” which is how we’re able to pull together all of the content for any given search term you see. You are able to see, in one place, the latest fertility related news, blogs, tweets, videos, images, articles and books.

We are excited by the positive feedback we have been receiving about fertilitywire.com. Here is one testimonial that sums up the experience very well:

“This website has a friendly approachable tone. It also covers so much, by the time I was done navigating, fertility issues seemed not intimidating but manageable and that there is a world that one could enter, (your center) and not be a stranger. At the same time, it seems like there is hope; if not here and now–it is being developed right around the corner.”

— Michael Lynn, PFC Patient

Visit fertilitywire.com. We hope you find everything you are searching for!

My husband and I have been riding the infertility roller coaster for almost 3 years now. The ups and downs have included invasive diagnostic testing, four failed intrauterine inseminations (IUIs) and most recently an unsuccessful in-vitro fertilization (IVF) attempt. Each wave of excitement over the hope brought on by the next treatment cycle would come crashing back down with the negative news. While I am confident I am receiving the best possible medical care with the team at PFC and am keeping “hope frozen in time” with my frozen embryos, it can still be a hard road to travel.

Considering my first attempt at IVF failed, you would think I would be at the lowest point of my journey towards parenthood. But, amazingly, I am not. I am sharing my story to tell you how I survived the ups and downs and was able to feel more grounded and

Lisa Wickham.

regained a sense of control in my life while continuing treatment.

This is what saved me: A powerful combination of group support and mind/body techniques.

My PFC acupuncturist (seeing tears stream down my face) recommended a Mind/Body class to help ease my obvious difficulty in coping with the emotional stress I was under. This was huge. This was the first step I would take in reclaiming my 0ormer self. What are Mind/ Body techniques? They are tools including deep breathing, meditation, guided imagery, progressive muscle relaxation, cognitive reframing, light yoga, tai chi and journaling exercises. My first thought was, “Will this be too ‘new age-y’ for me?” I could barely comprehend the fact that I was doing acupuncture regularly, let alone meditate.

The great thing about Mind/Body is that it is a tool box, so you pick what works for you. I never really did learn to meditate, but the regular use of relaxation CDs for deep breathing, muscle relaxation and guided imagery has given me profound peace of mind. Cognitive reframing (learning to recognize destructive thoughts and “reframe” them) was also powerful for me. I used to hear a tape playing in my head over and over, “I’ll never get pregnant, I’ll never get pregnant”. I learned to challenge the truth of that statement and rethink how it made me feel. A 10-week Mind/Body course I took was a key turning point. PFC offers a one-day workshop that offers an introduction to Mind/Body and is free for patients.

The other key component to my peace of mind has been meeting others who “get it”. It’s hard to explain to someone not experiencing infertility themselves just how this takes over your life. Well-meaning family and friends try to understand, but they truly cannot. Only my best friend, who also experienced difficulty in trying to conceive “got it”. That is, until I did my first IUI. Having to explain washed sperm to her and describe what it’s like to have your legs in stirrups as the washed sperm is inserted into you was beyond depressing. I knew I needed to meet others going through similar situations.

Lisa and Jonathan Wickham.

I attended my first Open Path group support meeting last year and had no idea what to expect. I only knew I needed to at least talk to someone else who knew what an IUI was. Open Path (fertilityandadoption.com) is a Bay Area organization that provides regular group support. There I met two amazing women and we are now a larger group of women who meet regularly and support each other over email, coffee and even cocktails in between cycling. We are a Sisterhood of Infertility. We all have different stories whether doing IUIs, IVF, using donor eggs, considering a gestational carrier or considering adoption. We have different personalities, some are quiet, some are loud, some blog their innermost thoughts to the online world (google “Stirrup Queens”), some are “closeted” with their infertility secret to all but a few. But our common thread is infertility. We all wear the red, pomegranate string around our wrists as a reminder that we are not alone (you can google “infertility’s common thread” to read more about this). We support each other when we are down and we celebrate our victories (small and large) together. While most of us could not find it in ourselves to feel happiness for friends we had known all our lives that got pregnant, we were able to give loud cheers of joy when one our IF Sisters did. This was healing beyond words. And this gives us hope.

I’ve heard the statistics about Mind/Body and group support increasing pregnancy success odds, but, for me, even more important than getting pregnant, was the peace of mind that came.

My hope is that my story can, in some way, help bring peace of mind to someone else as they navigate their own path. You are not alone. You do not have to do this alone. And there are concrete ways you can make yourself feel significantly better while undergoing treatment.

Try these resources for more information:

• Mind/Body @ PFC – pacificfertilitycenter.com/support/relax_workshop
• Open Path – fertilityandadoption.com
• Resolve – resolve.org
• Resolve support group listings: http://www.resolve.org/site/PageServer?pagename=npac_peer_groups

— Lisa Wickham, Current PFC Patient, San Francisco, CA

Special LGBT event happening tomorrow! We hope to see you there.

6:30 – 8:00 PM
LGBT Community Center
1800 Market St., San Francisco
Call 888-834-3095 or contact us for reservations

Attend an informative educational event on Wednesday, October 7th and hear firsthand from gay and lesbian parents about their family building experience. This is an opportunity to ask you specific questions and learn about advanced family building solutions.

Topics include:

* Selecting the right donor and/or surrogate
* Emotional & psychological aspects of gays & lesbians having children
* Hearing gay and lesbian parents accounts of their personal experience

Let Pacific Fertility Center be your guide on your journey to building a healthy family.

On May 15th, we were fortunate to have Dr. Daoshing Ni, D.O.M, L.AC., Ph.D., a Licensed Acupuncturist in the State of California, a Diplomat of Chinese Herbology, and a 76th generation acupuncturist come to speak at PFC about the benefits of combining acupuncture and ART.

Dr. Ni spoke about some of his own research studies on acupuncture and ART and also discussed some of the issues with the current protocols that are being used today. He emphasized that the Paulus protocol is a good guideline when doing embryo transfers, and he encouraged the addition of other supportive acupuncture points. He also strongly encouraged that patients be treated with Chinese medicine for at least 3 months before their ART cycle begins. Dr. Ni also spoke about how the use of Chinese herbs contribute to improving egg quality.

This outstanding program was attended by PFC’s acupuncturists, physicians, and staff. In addition, area wide acupuncturists were invited to hear Dr. Ni’s presentation, meet one another, and share ideas.

We are excited to introduce a new website FertilityWire, http://fertilitywire.com.  This site is separate from our current website www.pacificfertilitycenter.com.

FertilityWire will provide access to a wealth of fertility information, news, and social content. Please take a moment to check out this exciting new resource. You can let us know what you think in the comments section.

Enjoy!

-Robb Mayberry, Director of Development

Steve and I met and fell in love in our twenties. We both thought we would want children “some day.” Eleven years later we realized “some day” had finally arrived. I was thirty-six then, but I never thought we would have any problems conceiving. My mom had three children in her late thirties and into her forties.

After six months with no success, my doctor ran the usual tests and found nothing wrong, so my OB recommended going to PFC. We did one IUI, then decided to move on to IVF. My first IVF cycle failed. We were preparing for the second when we were delighted to findout I was pregnant naturally. I gave birth to a healthy baby boy.

We wanted more children, and as it had taken two and a half years to conceive Alan, we decided to start trying again straight away. We weren’t so lucky this time, so after 18 months we were back at PFC talking to Dr. Givens about doing IVF again. Then we discovered a new problem – my FSH was now elevated. So, now I also had decreased ovarian reserve in addition to unexplained infertility.

We tried four cycles of IVF with my own eggs. I did get pregnant on my third cycle, but sadly miscarried at eleven weeks. I was now forty-two and felt it was time to move on.

Now we faced decision time-do we give up, move on to donor egg, or move to adoption? We were both sure we wanted more children, and I felt that by carrying the child I would feel that it was truly mine, even if I didn’t have the biological connection. Oddly enough, it was harder for Steve to move on to an egg donor. But after lots of talking it through, he felt it was the best choice for our family too.

We met with Peggy the PFC counselor, who was very helpful. Dr. Givens thought an egg donor was a great option for us. She said that with a transfer of two blastocysts, our chances of conceiving were about 80%. We ended up with a short list of two potential donors. One was a perfect match on paper—my height, my hair color, my eye color, with the right ethnic background. The second wasn’t such a perfect match, but I just felt a really strong connection to her. I really felt that if we met in real life we would be friends. In my mind I kept going back to something Peggy had said “pick someone you really like”, it was great advice. We went with donor number two, and are very happy with our choice.

Initially everything went well, but then on day three we received a phone call asking us to come in. Our embryos were looking very stressed. Most were grade three with low cell count. We transferred the best three and prayed.

On the day of our beta pregnancy test, Ann (one of the nurses at PFC) called to give us the good news. I was pregnant! Once we saw the heartbeats, we told our son Alan, “Mommy has two babies growing in her tummy,” and he was thrilled. Feeling those babies kicking and squirming around inside, I had no doubt whose babies they were—I might not have provided the eggs, but my body turned those little seven or eight celled embryos into two beautiful children.

The first day Alan got to meet his new brother and sister the look on his face said it all. It was love at first sight. He has made a wonderful big brother, the twins adore him, and our family now feels complete. I feel truly lucky when I look at my three wonderful children. I am very grateful to Dr. Givens and all the wonderful staff at PFC, and especially to our donor.

Some people may wonder, if I love all of my children the same. They have three very different personalities, so I love them all differently; but I do love each one as much as the other. In the words of one of our favorite books, they are “all my favorites.”

—Submitted by Trisha (PFC patient)